Hepatitis B, HIV, and HBV-HIV Coinfection in a Nigerian Population and Gender-Specific Variations in Their Liver Function Parameters: Insights from a Study in Rivers State, Nigeria

Aaron Umasoye Udogadi; Agwu; Michael Ezenna; Ayodele Martins B. O.; John; Elizabeth Ovuru; Olugbenga Bamigbowu; Aniekan Affiah

doi:10.56201/ijmepr.v10.no6.2026.pg171.181

Hepatitis B, HIV, and HBV-HIV Coinfection in a Nigerian Population and Gender-Specific Variations in Their Liver Function Parameters: Insights from a Study in Rivers State, Nigeria

Aaron Umasoye Udogadi,, Agwu, Michael Ezenna,, Ayodele Martins B. O., John, Elizabeth Ovuru, Olugbenga Bamigbowu, and Aniekan Affiah

Abstract

Background: Liver dysfunction is a critical comorbidity in individuals infected with HIV and Hepatitis B Virus , particularly when coinfection occurs. This study aimed to evaluate liver function parameters across genders in patients with HIV, HBV, and HBV-HIV coinfection. This study was done to determine the liver function indicators in subjects who are human immunodeficiency and Hepatitis B positive. Methodology: A total of 100 participants were categorized into control, HBV-positive, HIV-positive, and HBV-HIV coinfected groups. Liver function markers including total and direct bilirubin, AST, ALT, alkaline phosphatase, GGT, total protein, albumin, and globulin were measured and analyzed. Significant differences (p < 0.05) were observed in AST, alkaline phosphatase, and total protein across groups. One hundred (100) subjects made up of Twenty five (25) each for HIV Positive, Hepatitis B virus positive and HIV- Hepatitis B Virus coinfection Positive had their aspartate aminotransferase , alanine aminotransferase ,Gammma glutamyl transpeptidase , Alkaline Phosphatase , Bilirubin, and Proteins determined using VITROS 250/350/950/5,1 FS and 4600 Chemistry Systems and the VITROS 5600 Integrated System manufactured by Ortho-Clinical Diagnostics, Inc. Results: Females with HBV exhibited significantly higher GGT and alkaline phosphatase levels compared to males, suggesting gender-related hepatic vulnerability. The result showed that there was significant difference (P<0.05) in activities of AST, ALP, Total Protein and globulin concentrations in HIV Positive, Hepatitis B virus positive and HIV-Hepatitis B Virus coinfection Positive while there was no significant difference in bilirubin, albumin concentrations as well as GGT and ALT activities in HIV Positive, Hepatitis B virus positive and HIV-Hepatitis B Virus coinfection Positive. The result of the study has shown that there was liver dysfunction in HIV Positive, Hepatitis B virus positive and HIV-Hepatitis B Virus coinfection Positive. Conclusion: This study highlights the importance of gender-sensitive diagnostic and therapeutic strategies in managing liver-related complications in HIV and HBV-infected individuals. IJMEPR Keyword: Liver function, HIV, Hepatitis B, aspartate aminotranferase , alanine aminotranferase , Gammma glutamyl transpeptidase , Alkaline Phosphatase , Bilirubin, and Proteins.

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Hepatitis B, HIV, and HBV-HIV Coinfection in a Nigerian Population and Gender-Specific Variations in Their Liver Function Parameters: Insights from a Study in Rivers State, Nigeria

Abstract

References

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