Effects of Nicotine withdrawal on the Plasma Lipid Profile of Wistar Rats fed with High-fat diet

Bellinger, L. L., Wellman, P. J., Harris, R. B., Kelso, E. W., & Kramer, P. R. (2010). The effects of chronic nicotine on meal patterns, food intake, metabolism and body weight of male rats. Pharmacology, biochemistry, and behavior, 95(1), 92–99. https://doi.org/10.1016/j.pbb.2009.12.012 Binayi, F., Moslemi, M., Khodagholi, F., Hedayati, M., & Zardooz, H. (2020). Long-term high-fat diet disrupts lipid metabolism and causes inflammation in adult male rats: possible intervention of endoplasmic reticulum stress. Archives of Physiology and Biochemistry, 129(1), 204–212. https://doi.org/10.1080/13813455.2020.1808997 Calarco, C. A., & Picciotto, M. R. (2020). Nicotinic Acetylcholine Receptor Signaling in the Hypothalamus: Mechanisms Related to Nicotine's Effects on Food Intake. Nicotine & tobacco research: official journal of the Society for Research on Nicotine and Tobacco, 22(2), 152–163. https://doi.org/10.1093/ntr/ntz010 Chellian, R., Behnood-Rod, A., Bruijnzeel, D. M., Wilson, R., Pandy, V., & Bruijnzeel, A. W. (2021). Rodent models for nicotine withdrawal. Journal of psychopharmacology (Oxford, England), 35(10), 1169–1187. https://doi.org/10.1177/02698811211005629 Cho, E. R., Brill, I. K., Gram, I. T., Brown, P. E., & Jha, P. (2024). Smoking Cessation and Short- and Longer-Term Mortality. NEJM evidence, 3(3), EVIDoa2300272. https://doi.org/10.1056/EVIDoa2300272 da Costa Peres, C. M., Gardone, D. S., Costa, B. V. L., Duarte, C. K., Pessoa, M. C., & Mendes, L. L. (2020). Retail food environment around schools and overweight: a systematic review. Nutrition reviews, 78(10), 841–856. https://doi.org/10.1093/nutrit/nuz110 de Albuquerque, F. M., Pessoa, M. C., De Santis Filgueiras, M., Gardone, D. S., & de Novaes, J. F. (2022). Retail food outlets and metabolic syndrome: a systematic review of longitudinal studies. Nutrition reviews, 80(6), 1599–1618. https://doi.org/10.1093/nutrit/nuab111 Dangana, E. O., Omolekulo, T. E., Areola, E. D., Olaniyi, K. S., Soladoye, A. O., & Olatunji, L. A. (2020). Sodium acetate protects against nicotine-induced excess hepatic lipid in male rats by suppressing xanthine oxidase activity. Chemico- biological interactions, 316, 108929. https://doi.org/10.1016/j.cbi.2019.108929 Driva, S., Korkontzelou, A., Tonstad, S., Tentolouris, N., & Katsaounou, P. (2022). The Effect of Smoking Cessation on Body Weight and Other Metabolic Parameters with Focus on People with Type 2 Diabetes Mellitus. International journal of environmental research and public health, 19(20), 13222. https://doi.org/10.3390/ijerph192013222 Emmanuel, F. D., Obia, O., Charles, C., Okari, K. A., Otto, J. B., Reuben, E., & Onyeso, G. (2025). Comparative Assessment of Red, Green and Black pepper species on Plasma and Fecal Lipid Profile of High-fat diet fed wistar rats. International Journal of Biochemistry Research & Review, 34(1), 153 163. Gepner, A. D., Piper, M. E., Johnson, H. M., Fiore, M. C., Baker, T. B., & Stein, J. H. (2011). Effects of smoking and smoking cessation on lipids and lipoproteins: outcomes from a randomized clinical trial. American heart journal, 161(1), 145–151. https://doi.org/10.1016/j.ahj.2010.09.023 Hasan, H., Arhouma, T., Khanfar, M., & Azzam, M. (2022) Study the Relationship between the Nicotine and Lipid Profile with Some Hematology Parameters in Serum of Smoker and Non-Smoker Blood Samples. Journal of Biosciences and Medicines, 10, 20-36. doi: 10.4236/jbm.2022.106003. Hu, H., Nakagawa, T., Honda, T., Yamamoto, S., & Mizoue, T. (2024). Association of conventional cigarette smoking, heated tobacco product use and dual use with hypertension. International journal of epidemiology, 53(5), dyae114. https://doi.org/10.1093/ije/dyae114 Jha, P., Ramasundarahettige, C., Landsman, V., Rostron, B., Thun, M., Anderson, R. N., McAfee, T., & Peto, R. (2013). 21st-century hazards of smoking and benefits of cessation in the United States. The New England journal of medicine, 368(4), 341– https://doi.org/10.1056/NEJMsa1211128 Kondo, T., Nakano, Y., Adachi, S., & Murohara, T. (2019). Effects of Tobacco Smoking on Cardiovascular Disease. Circulation journal: official journal of the Japanese Circulation Society, 83(10), 1980–1985. Li, J., Wu, H., Liu, Y., & Yang, L. (2020). High fat diet induced obesity model using four strainsof mice: Kunming, C57BL/6, BALB/c and ICR. Experimental animals, 69(3), 326–335. https://doi.org/10.1538/expanim.19-0148 Liakoni, E., Edwards, K. C., St Helen, G., Nardone, N., Dempsey, D. A., Tyndale, R. F., & Benowitz, N. L. (2019). Effects of Nicotine Metabolic Rate on Withdrawal Symptoms and Response to Cigarette Smoking After Abstinence. Clinical pharmacology and therapeutics, 105(3), 641–651. https://doi.org/10.1002/cpt.1238 Liu, M., Chuang Key, C. C., Weckerle, A., Boudyguina, E., Sawyer, J. K., Gebre, A. K., Spoo, W., Makwana, O., & Parks, J. S. (2018). Feeding of tobacco blend or nicotine induced weight loss associated with decreased adipocyte size and increased physical activity in male mice. Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association, 113, 287–295. https://doi.org/10.1016/j.fct.2018.01.058 Maddatu, J., Anderson-Baucum, E., & Evans-Molina, C. (2017). Smoking and the risk of type 2 diabetes. Translational research: the journal of laboratory and clinical medicine, 184, 101–107. https://doi.org/10.1016/j.trsl.2017.02.004 Momayyezi, M., Jambarsang, S., Fallahzadeh, H., & Sefidkar, R. (2024). Association between lipid profiles and cigarette smoke among adults in the Persian cohort (Shahedieh) study. BMC Public Health 24, 1256. https://doi.org/10.1186/s12889-024- 18734-0 Nath, M. C., Rahman, A. K. M. S., Nath, M. C., Dutta, A., Khan, Z. H., Ghosh, E., Akhter, S., Islam, M. S., Sultana, S., Begum, R., & Rahman, M. M. (2022). The Effect of Cigarette Smoking on Fasting Lipid Profile: A Single Center Study. Fortune Journal of Health Sciences, 5(2): 363-373. Nwafor, A., Mmom, F., Obia, O., Obiandu, C., Hart, V. O., & Chinko, B. C. (2015). Relationship Between Blood Pressure, BloodGlucose And Body Mass Index And Coexisting Prehypertension And Prediabetes Among Rural Adults In Niger Delta Region,Nigeria. British Journal of Medicine and Medical Research. 9 (7), 1-12. Obia, O., Efone, P. E., & Wichendu, P. N. (2015). Effect of Exercise on the Blood Pressure of Cigarette Smokers. The International journal of innovative research and development, 4 (8), 88–90. Obia, O., Nda-ue, L., Ojeka, S. O., Ogba, A., & Nwokocha, F. N. (2024). Impact of Nicotine Exposure and Withdrawal on Plasma Glucose, Insulin and Glycated Hemoglobin in High-fat diet fed Wistar Rats. East African Scholars Journal of Medical Sciences. 7(4), 138-143. Obia, O., Kalio, R. O., Tee, P. G. P., & Onyeso, G. (2025). Plasma Lipid Lowering Potential of Carrot (Daucus carota) Extract in Male Wistar Rats. Asian Journal of Research in Medical and Pharmaceutical Sciences, 14(1), 18-23. Parmar, M. P., Kaur, M., Bhavanam, S., Mulaka, G. S. R., Ishfaq, L., Vempati, R., C, M. F., Kandepi, H. V., Er, R., Sahu, S., & Davalgi, S. (2023). A Systematic Review of the Effects of Smoking on the Cardiovascular System and General Health. Cureus, 15(4), e38073. https://doi.org/10.7759/cureus.38073 Rupprecht, L. E., Kreisler, A. D., Spierling, S. R., de Guglielmo, G., Kallupi, M., George, O., Donny, E. C., Zorrilla, E. P., & Sved, A. F. (2018). Self-administered nicotine increases fat metabolism and suppresses weight gain in male rats. Psychopharmacology, 235(4), 1131–1140. Sansone, L., Milani, F., Fabrizi, R., Belli, M., Cristina, M., Zagà, V., de Iure, A., Cicconi, L., Bonassi, S., & Russo, P. (2023). Nicotine: From Discovery to Biological Effects. International journal of molecular sciences, 24(19), 14570.