IIARD International Institute of Academic Research and Development

INTERNATIONAL JOURNAL OF MEDICAL EVALUATION AND PHYSICAL REPORT (IJMEPR )

E-ISSN 2579-0498
P-ISSN 2695-2181
VOL. 9 NO. 1 2025
DOI: 10.56201/ijmepr.v9.no1.2025.pg152.184

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Nanocarriers for Targeted Drug Delivery in Cancer Therapy: Innovations and Challenges Busayo Olamide Tomoh

Stephen Vure Gbaraba , Ashiata Yetunde Mustapha , Akachukwu Obianuju Mbata , and Adelaide Yeboah Forkuo Corresponding Author Email:

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Abstract

Nanocarriers have revolutionized the field of targeted drug delivery in cancer therapy, offering enhanced specificity and reduced side effects compared to traditional treatments. These nanoscale delivery systems, including liposomes, dendrimers, and polymeric nanoparticles, are engineered to deliver chemotherapeutic agents directly to cancer cells, thus sparing healthy tissues. The ability of nanocarriers to enhance the pharmacokinetics and biodistribution of anticancer drugs has led to significant improvements in therapeutic outcomes and patient quality of life. Innovations in nanocarrier technology have focused on improving targeting efficiency and drug release mechanisms. Active targeting strategies, such as ligand-receptor interactions, enable nanocarriers to selectively bind to cancer cell surface markers, enhancing drug accumulation in tumor tissues. Additionally, stimuli-responsive nanocarriers, which release their payload in response to specific internal or external triggers (e.g., pH, temperature, or light), provide controlled and on-demand drug release, minimizing systemic toxicity and improving therapeutic efficacy. Recent advancements include the development of multifunctional nanocarriers capable of simultaneous imaging and therapy (theranostics), which allow for real-time monitoring of drug delivery and treatment response. These innovations are paving the way for personalized cancer therapy, where treatment regimens can be tailored to the individual patient's tumor profile and disease progression. Despite the promising potential, several challenges remain in the clinical translation of nanocarrier-based therapies. Manufacturing complexities, scalability issues, and stringent regulatory requirements pose significant barriers to commercialization. Additionally, biological challenges such as immune system recognition and clearance, potential toxicity, and the heterogeneity of tumor environments complicate the effect

keywords:

Nanocarriers; Drug Delivery; Cancer Therapy; Innovations; Challenges

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